Application of Titanium in the Pharmaceutical Industry

The pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceuticals, medical machinery, sanitary materials and other fields, and occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry because it is non-toxic and harmless and has good compatibility with the human body.

In pharmaceutical production, since the production of medicines cannot do without acid, alkali, and salt, pharmaceutical equipment is easily corroded and damaged. The use of steel equipment not only cannot solve the problem of serious equipment corrosion, but also causes a lot of loss of manpower, material resources, and financial resources, which affects normal production. The use of titanium equipment is a good solution to this problem.

In the production of several major commonly used drugs, the equipment made of titanium has good corrosion resistance and has obtained considerable economic benefits.

1. Production of Vitamin B1

In our country, the hydrogen chloride conversion method is used to produce vitamin B1, and the finished product is dried by a cyclone and separated by two cyclones. The medium is thiamine hydrochloride, the PH value is 2.5, and the temperature is 110°C, which is very corrosive. The original drying device is made of stainless steel, and the inner wall has been corroded and perforated after more than a year of use, which seriously pollutes the medicine.

After using titanium screw feeder, cyclone separator, vortex body, hopper, discharge pipe and tail gas box titanium lining, the production qualification rate of vitamin B1 has increased from 95% to 100%, and the equipment has been used for more than 7 years without corrosion , The cost of using titanium can be recovered in 3 months.

2. Production of Vitamin C

Vitamin C is made of sorbitol, fermented with black vinegar bacteria into sorbose, and then fermented with Pseudomonas bacterium to produce low-concentration gulonic acid. After concentration, it is converted into finished product by hydrogen chloride.

Titanium is very resistant to corrosion in high-temperature colognic acid. In the production process of this product, a titanium tube and tube heat exchanger, a titanium DHC-500 disc sinker automatic slag discharge centrifuge, and a TC4 cast impeller are used. No corrosion has been found after many years of use.

3. Production of antibiotics

The main raw material for the chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% chlorinated alkene and trichloroethylene. If steel equipment is used in the refining process, severe corrosion is likely to occur, so use titanium instead The equipment has remained intact since it was manufactured.

4. Production of anesthetics

Procaine hydrochloride used for local anesthesia, its production uses p-nitrotoluene as a raw material. It is highly corrosive during the entire production process of oxidation to prepare p-nitrobenzoic acid, acetic acid washing, and mother liquor recovery, so the production equipment A titanium steel composite plate inner cylinder, titanium bubbling tube, glacial acetic acid circulating condenser and vapor-liquid separator are used to solve the corrosion problem.

5. Production of anthelmintics and other medicines

Qufangjing (tetraimidazole) is a highly effective intestinal nematode anthelmintic. In the production of this product, stainless steel equipment was originally used. The product was polluted due to corrosion. The corrosion problem was successfully solved after the use of titanium as the feed pipe and the pump inlet pipe. .

Nitrochlorophenol is a special veterinary medicine for treating Fasciola hepatica in cattle and sheep. It is produced with sulfuric acid, nitric acid, glacial acetic acid and chlorine-containing solution. The use of titanium-made marketing tank stirrer has been operating normally so far. In addition, activated carbon is commonly used for decolorization in pharmaceutical production. After the stainless steel suction filter is changed to a titanium suction filter, it is still intact after 9 years of use.

In the production of brominated amino acids abroad, titanium reactors are used in the processes of bromination, separation, salting out, extraction, and steaming. The use of quinoline derivatives in the preparation of malaria drugs, schistosomiasis drugs that are exposed to chloride ions, contraceptives, rheumatism, etc. also require the use of titanium equipment. Others such as penicillin esterification kettle, saccharification tank, chloramphenicol thin film evaporator, analgin reactor, metol filter, dimethyl sulfate cooler, chemical liquid filter, etc., are all made of titanium materials. Sex and necessity.

Nicole